SeQuent® Please OTW

SeQuent® Please OTW features an optimized and clinically proven drug-coating technology which facilitates the safe and effective treatment of patients with peripheral arterial disease (PAD) in above and below the knee indications. ^{[1, 2]}

As pioneers and global market leaders in drug-coated balloon catheter technologies that help interventionalists achieve the treatment strategy of leaving (almost) nothing behind, B. Braun brings extensive knowledge to the peripheral field with the SeQuent® Please OTW.

An effective next generation combination of Paclitaxel and Resveratrol ^[1,2]

SeQuent® Please OTW features an optimized and clinically proven drug-coating technology which facilitates the safe and effective treatment of patients with peripheral arterial disease.

Long-term efficacy with short-term drug release ^[1,2]

• Paclitaxel with an effective drug dose of 3μg/mm² ^[3,4]
• Significant reduction of TLR and in late lumen loss (LLL) compared to uncoated balloons ^[1,2,5]

Resveratrol: A naturally occurring matrix builder

• Naturally occurring, plant-based substance found for example in the skin of red grapes & raspberries ^[5]
• Acts as matrix builder and makes the Paclitaxel bioavailable ^[5]
• Enables fast and effective drug transfer into vessel wall ^[5]

Mechanically resistant coating (5)

• Homogeneous coating even in the balloon folds exceeding distal and proximal markers ^[5]
• Low drug loss in simulated use ^[5]
• Efficient available drug dose at inflation ^[1,2,5]

CONSEQUENT Demonstrates Safety and Efficacy

Safety and efficacy of SeQuent® Please OTW was demonstrated in an unselected, all comers cohort ^[2] whereas two-year efficacy and safety was shown in the CONSEQUENT RCT ^[1,4].